Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.

نویسندگان

  • Ruth A Bryan
  • Zewei Jiang
  • Xianchun Huang
  • Alfred Morgenstern
  • Frank Bruchertseifer
  • Rani Sellers
  • Arturo Casadevall
  • Ekaterina Dadachova
چکیده

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

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Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 53 4  شماره 

صفحات  -

تاریخ انتشار 2009